Pomegranate[1] refers to the fruit of the Punica granatum plant which grows as a small shrub or tree with spiny branches. The Pomegranate tree is extremely long-lived, with some specimens in France surviving for 200 years
Composition
Healing Properties
Antioxidant
Anti-Inflammatory
Brain Health
- Urolithins are a specific constituent of pomegranate extrac that meet the necessary criteria for Blood-Brain Barrier (BBB) penetration.[1:1]
- In vitro studies showed that urolithins were able to prevent the fibrillation of Aβ, while methyl-urolithin B had a protective effect against Aβ-induced neurotoxicity and paralysis.[1:2]
- Urolithins A and B can lower levels of nitric oxide and reduce the expression of proinflammatory genes (TNF-α, IL-6, IL-1β, inducible nitric oxide synthase [iNOS], and cyclooxygenase-2 [COX-2]) in microglia treated with lipopolysaccharides (LPS).[1:3]
- Urolithins A and B can inhibit the activation of signaling pathways (ERK1/2, p38 MAPK, Akt, nuclear factor kappa B [NF-κB]) involved in inflammation.[1:4]
Endothelial Health
Helps repair the inner lining of blood vessels.
Disease / Symptom Treatment
Alzheimer’s Disease
- Urolithin compounds in pomegranate are able to cross the BBB and contribute to its anti-Alzheimer’s disease effects.[1:5]
Title: Modulatory Effects of Phytochemicals on Gut–Brain Axis: Therapeutic Implication
Publication: Current Developments in Nutrition
Date: June 2024
Author(s): Khojasteh Rahimi Jaberi, Vahab Alamdari-palangi, Amir Savardashtaki, Pooya Vatankhah, Tannaz Jamialahmadi, Amir Tajbakhsh, Amirhossein Sahebkar
Institution(s): Mashhad University of Medical Sciences, Mashhad, Iran; Shiraz University of Medical Sciences, Shiraz, Iran
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Study Type: Animal Study, Commentary, Human Study: In Vitro - In Vivo - In Silico, Human: Case Report, Meta Analysis, Review
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